Beyond the Norm

Evidence & References

The science behind every solution we offer.

At Beyond the Norm, we believe in evidence-led action. Every product, protocol, and insight we recommend is grounded in clinical research, peer-reviewed studies, and real-world application.

This reference library exists to make the science accessible, transparent, and practically useful — whether you're a practitioner, clinic, coach, or simply someone who wants to make informed decisions about your health.

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A clinical trial of cranial electrotherapy stimulation for anxiety and comorbid depression

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

A comparative study of anxiety disorders treatment with Paroxetine in combination with cranial electrotherapy stimulation therapy

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

A control study of a hypnotic drug plus cranial electrotherapy stimulation in the treatment of insomnia

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

A novel medical device that relieves anxiety, depression and pain while improving sleep in a population of teachers

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Sleep Optimisation
Anxiety & Stress Reduction
Mood Support
Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

A progressive treatment for a chronic progressive disease: the war against complex regional pain syndrome

Evidence Level

Case Reports & Case Series

Quality Rating

Low

Outcomes

Pain Management

Modality

Microcurrent Therapy

A qualitative study exploring the experience and value of the Cranial Electrotherapy Stimulation (CES) device Alpha-Stim AID for social prescribing service patients with symptoms of Anxiety

Evidence Level

Case Reports & Case Series

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

A randomized, controlled, double-blind pilot study of the effects of cranial electrical stimulation on activity in brain pain processing regions in individuals with fibromyalgia

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

A retrospective review of patient perception of Alpha-Stimulation treatment

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Sleep Optimisation
Anxiety & Stress Reduction
Mood Support
Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

Acupuncture combined with cranial electrotherapy stimulation on generalized anxiety disorder: A randomized controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Alpha-Stim AID cranial electrotherapy stimulation (CES) anxiety treatment: anxiety, depression and health-related quality-of-life outcomes in primary health-care social prescribing services

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Alpha-Stim Cranial Electrotherapy Stimulation (CES) for Anxiety Treatment: Outcomes in a United Kingdom (UK) Primary Care Practice

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Alpha-Stim Cranial Electrotherapy Stimulation(CES) for Anxiety Treatment: Outcomes in a United Kingdom (UK) Primary Care Practice

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

An examination of cranial electrotherapy stimulation (CES) on alpha-amylase levels, cortisol levels and state-trait anxiety scores in the chronically mentally ill

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Focus & Cognitive Clarity
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

An investigation of the effectiveness of cranial electrotherapy stimulation in the treatment of anxiety disorders among outpatient psychiatric patients, impulse control parolees and pedophiles

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Focus & Cognitive Clarity
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Bioelectricity and microcurrent therapy for tissue healing – a narrative review

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Moderate

Outcomes

No items found.

Modality

Microcurrent Therapy

Biofeedback and electromedicine reduce the cycle of pain spasm pain in low back patients

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Microcurrent Therapy

Clinical Efficacy of Assisted Cranial Electrotherapy Stimulation Treatment on Depression

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support
Anxiety & Stress Reduction
Focus & Cognitive Clarity
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Clinical comparative study of microcurrent electrical stimulation to mid-laser and placebo treatment in degenerative joint disease of the temporomandibular joint

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anti-Inflammatory Support
Recovery & Rehabilitation
Pain Management

Modality

Microcurrent Therapy

Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder

Evidence Level

Systematic Reviews & Meta-Analyses of RCTs

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support
Sleep Optimisation
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalized anxiety disorder

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Sleep Optimisation
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Comparative Observation between Single Use of Fluoxetine and Its Combination with CES

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Comparative Study of Pain Relief in Two Non-Pharmacological Treatments in Patients with Partial Rotator Cuff Tears: A Randomized Trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anti-Inflammatory Support
Pain Management
Recovery & Rehabilitation

Modality

Microcurrent Therapy

Comparison of the effects of cranial electrotherapy stimulation and midazolam as preoperative treatment in geriatric patients: A CONSORT-compliant randomized controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial application of low level transcranial electrotherapy vs. relaxation instruction in anxious patients

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Focus & Cognitive Clarity
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrical stimulation improves symptoms and functional status in individuals with fibromyalgia

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Sleep Optimisation
Mood Support
Anxiety & Stress Reduction

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation (CES) As a treatment for reducing stress and improving prefrontal cortex functioning in victims of domestic violence

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation (CES) and the reduction of stress symptoms in a sheriff’s jail security and patrol officer population: a pilot study

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation (CES): a safe and effective low cost means of anxiety control in a dental practice

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation affects mood state but not levels of peripheral neurotrophic factors or hypothalamic-pituitary-adrenal axis regulation

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Mood Support
Focus & Cognitive Clarity

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation for the management of depression, anxiety, sleep disturbance, and pain in patients with advanced cancer: a preliminary study

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Sleep Optimisation
Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation for the treatment of chronically symptomatic bipolar patients

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Cranial electrotherapy stimulation in patients suffering from acute anxiety disorders

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction

Modality

Cranial Electrotherapy Stimulation (CES)

Cumulative Response from Cranial Electrotherapy Stimulation (CES) for Chronic Pain

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

Curative effect of CES as adjuvant therapy on elderly patients with chronic insomnia

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Sleep Optimisation
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Differential effects of cranial electrotherapy stimulation on changes in anxiety and depression symptoms over time in patients with generalized anxiety disorder

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Early Recovery of Exercise-Related Muscular Injury by HBOT: A Randomized, Double-Blind, Controlled Clinical Trial (2019)

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effect of CES Combined with Flupentixol-melitracen for Depression After Stroke

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Effect of CES combined with escitalopram on quality of life and activities of daily living of patients with depression after cerebral infarction

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Effect of HBOT on mood and neurohormonal markers

Evidence Level

Cross-Sectional Studies / Surveys

Quality Rating

Moderate

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effect of hyperbaric oxygen therapy on inflammatory cytokines, oxidative stress markers, and recovery in aging

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Ageing & Longevity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effect of hyperbaric oxygen therapy on inflammatory cytokines, oxidative stress markers, and recovery in aging.

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effect of hyperbaric oxygen therapy on muscle recovery and performance enhancement in football players: A cohort study

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effect of transcutaneous electrical nerve stimulation for controlling pain associated with orthodontic tooth movement

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Microcurrent Therapy

Effectiveness of microcurrent therapy as a constituent of post-hospital rehabilitative treatment in patients after total knee alloarthroplasty - a randomized clinical trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Recovery & Rehabilitation

Modality

Microcurrent Therapy

Effects of Acute Microcurrent Electrical Stimulation on Muscle Function and Subsequent Recovery Strategy

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

Low

Outcomes

No items found.

Modality

Effects of Cranial Electrotherapy Stimulation on Suicidal Ideation and Event-related Potentials in Patients with Treatment-resistant Depression

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support
Anxiety & Stress Reduction

Modality

Cranial Electrotherapy Stimulation (CES)

Effects of Cranial Electrotherapy Stimulation on the Levels of HPA, BDNF and Clinical Symptoms in Patients with Mild Depression

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Effects of HBOT on sleep disorders in older adults

Evidence Level

Cross-Sectional Studies / Surveys

Quality Rating

Moderate

Outcomes

Sleep Optimisation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of Hyperbaric Oxygen Therapy on Mitochondrial Respiration and Physical Performance in Middle-Aged Athletes: A Blinded, Randomized Controlled Trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of Hyperbaric Oxygen Therapy on Mitochondrial Respiration and Physical Performance in Middle-Aged Master Athletes (2022)

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of cranial electrotherapy stimulation on preoperative anxiety, pain and endocrine response

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Pain Management
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

Effects of hyperbaric oxygen on oxidative stress and mitochondrial function in exercise-induced muscle damage in rats

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of hyperbaric oxygen therapy on cellular aging and immune function.

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Ageing & Longevity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of hyperbaric oxygen therapy on exercise-induced muscle injury and soreness: A systematic review and meta-analysis (2025)

Evidence Level

Systematic Reviews & Meta-Analyses of RCTs

Quality Rating

High

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of hyperbaric oxygen therapy on muscle strength and endurance in elite athletes: A randomised controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of hyperbaric oxygen therapy on oxidative stress and mitochondrial function in patients with chronic fatigue syndrome

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Effects of microcurrent electrical neuromuscular stimulation on recovery of muscle performance after high-intensity sprint and resistance combined training sessions

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Anti-Inflammatory Support
Performance Enhancement
Recovery & Rehabilitation

Modality

Microcurrent Therapy

Efficacy of Cranial Electrotherapy Stimulation on Anxiety and Sleep Qualities Among Elderly Patients with Chronic Sleep Disorders

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction
Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Efficacy of HBOT in muscle recovery post-exercise: a double-blind, placebo-controlled RCT

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Efficacy of cranial electric stimulation for the treatment of insomnia: A randomized pilot study

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Efficacy of cranial electrotherapy stimulation for neuropathic pain following spinal cord injury: a multi-site randomized controlled trial with a secondary 6-month open-label phase

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Efficacy of microcurrent therapy in infants with congenital muscular torticollis involving the entire sternocleidomastoid muscle: a randomized placebo-controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anti-Inflammatory Support
Anxiety & Stress Reduction
Recovery & Rehabilitation

Modality

Microcurrent Therapy

Electrical treatment of severe head and neck cancer pain

Evidence Level

Case Reports & Case Series

Quality Rating

Low

Outcomes

Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

Electro-membrane microcurrent therapy reduces signs and symptoms of muscle damage

Evidence Level

Quality Rating

High

Outcomes

Anti-Inflammatory Support
Recovery & Rehabilitation
DOMS

Modality

Microcurrent Therapy

Evaluation of the potential efficacy of the Alpha-Stim SCS in the horse

Evidence Level

Case Reports & Case Series

Quality Rating

Low

Outcomes

Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Feasibility of Using Cranial Electrotherapy Stimulation for Pain in Persons with Parkinson’s Disease

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Pain Management
Mood Support
Anxiety & Stress Reduction
Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Feasibility, acceptability and costs of nurse-led Alpha-Stim cranial electrostimulation to treat anxiety and depression in university students

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Feasibility, acceptability and costs of nurse‑led Alpha‑Stim cranial electrostimulation to treat anxiety and depression in university students

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Anxiety & Stress Reduction
Mood Support
Recovery & Rehabilitation

Modality

Cranial Electrotherapy Stimulation (CES)

First responder research shows that electrical brain stimulation helps control anxiety, insomnia, and depression

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction
Mood Support
Sleep Optimisation
Pain Management

Modality

Cranial Electrotherapy Stimulation (CES)

HBOT and GABA receptor regulation

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

HBOT enhances fibroblast proliferation and collagen synthesis

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

HBOT for elite athletes: implications on VO2 max, recovery, and inflammation markers

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen and neuroplasticity: Implications for well-being and cognitive function in aging populations

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen and neuroplasticity: Implications for well-being and cognitive function in aging populations.

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Ageing & Longevity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen and sports performance: A look at potential applications and outcomes

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen effects on long COVID patients: A clinical trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen in sleep-deprived subjects: Recovery acceleration

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Sleep Optimisation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy ameliorates cognitive impairment induced by chronic intermittent hypoxia in rats

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Ageing & Longevity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy ameliorates cognitive impairment induced by chronic intermittent hypoxia in rats

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy ameliorates cognitive impairment induced by chronic intermittent hypoxia in rats.

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Precision & Personalised Health

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy and its role in inflammation modulation

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Anti-Inflammatory Support

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy effects on stress hormone levels and parasympathetic activity

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy for sports-related injuries: a systematic review and meta-analysis

Evidence Level

Systematic Reviews & Meta-Analyses of RCTs

Quality Rating

High

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy for the recovery of soccer players: A randomized controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Recovery & Rehabilitation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy for the treatment of mitochondrial dysfunction

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy improves cognitive function in healthy aging adults.

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Metabolic Health

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy improves mitochondrial function and biogenesis in hypoxic cells

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Performance Enhancement

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy improves neurocognitive function in healthy aging adults

Evidence Level

Cohort Studies

Quality Rating

Low

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy improves sleep quality in patients with chronic fatigue

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Sleep Optimisation

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy in post-COVID fatigue

Evidence Level

Expert Opinion / Mechanistic Reasoning / Lab Studies

Quality Rating

Low

Outcomes

Anxiety & Stress Reduction

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in humans.

Evidence Level

Systematic Reviews & Meta-Analyses of RCTs

Quality Rating

High

Outcomes

Ageing & Longevity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen treatment improves oxidative stress levels and cognitive decline in elderly patients

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Hyperbaric oxygen treatment improves oxidative stress levels and cognitive decline in elderly patients: A controlled clinical trial.

Evidence Level

Cohort Studies

Quality Rating

Moderate

Outcomes

Focus & Cognitive Clarity

Modality

Hyperbaric Oxygen Therapy (HBOT)

Impact of Cranial Electrotherapy Stimulation Based Analysis of Heart Rate Variability in Insomnia

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Sleep Optimisation

Modality

Cranial Electrotherapy Stimulation (CES)

Incorporating complementary and alternative medicine (CAM) therapies to expand psychological services to veterans suffering from chronic pain

Evidence Level

Open-Label Clinical Trial

Quality Rating

Low

Outcomes

Pain Management
Sleep Optimisation
Anxiety & Stress Reduction
Mood Support

Modality

Cranial Electrotherapy Stimulation (CES)

Is microcurrent stimulation effective in pain management? An additional Perspective

Evidence Level

Case Reports & Case Series

Quality Rating

Low

Outcomes

Pain Management

Modality

Microcurrent Therapy

Microcurrent electrotherapy improves palatal wound healing: randomized clinical trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Skin & Aesthetic Health
Wound Healing

Modality

Microcurrent Therapy

Microcurrent stimulation at shenmen acupoint facilitates EEG associated with sleepiness and positive mood: a randomized controlled electrophysiological study

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Sleep Optimisation

Modality

Microcurrent Therapy

Microcurrent therapy in the treatment of knee osteoarthritis. Could it be more than a placebo-effect? A randomized controlled trial

Evidence Level

Randomised Controlled Trials (RTCs)

Quality Rating

High

Outcomes

Anti-Inflammatory Support
Pain Management
Recovery & Rehabilitation

Modality

Microcurrent Therapy
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